Tunica Mississippi is a little Las Vegas with wonderful resorts, Hotels and casinos. It is located in the Delta famous for cotton farming and is a terrific place to enjoy southern style food and hospitality. It is located on the famous Mississippi Blues trail and has lots of history behind it. If you enjoy great food, great entertainment in a small southern town take a few days off and spend the weekend in Tunica, Mississippi.. Right on the bank of the Ol Mississippi you can watch the waters of the most famous river in America just roll on by. Rolling, rolling rolling on the river! Tunica!